Co-existence and co-infection of influenza A viruses and coronaviruses: Public health challenges

作者：Jing Yang, Yuhuan Gong, Chunge Zhang, Ju Sun, Gary Wong, Weifeng Shi, Wenjun Liu, George F. Gao, Yuhai Bi · 发表于：The Innovation · 年份：2022 · DOI：10.1016/j.xinn.2022.100306 · 被引用次数：60 · 研究领域：SARS-CoV-2 and COVID-19 Research、COVID-19 epidemiological studies、Viral Infections and Outbreaks Research

century, humans have lived through five pandemics caused by influenza A viruses (IAVs) (H1N1/1918, H2N2/1957, H3N2/1968, and H1N1/2009) and the coronavirus (CoV) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IAVs and CoVs both have broad host ranges and share multiple hosts. Virus co-circulation and even co-infections facilitate genetic reassortment among IAVs and recombination among CoVs, further altering virus evolution dynamics and generating novel variants with increased cross-species transmission risk. Moreover, SARS-CoV-2 may maintain long-term circulation in humans as seasonal IAVs. Co-existence and co-infection of both viruses in humans could alter disease transmission patterns and aggravate disease burden. Herein, we demonstrate how virus-host ecology correlates with the co-existence and co-infection of IAVs and/or CoVs, further affecting virus evolution and disease dynamics and burden, calling for active virus surveillance and countermeasures for future public health challenges.