Altered dynamic intrinsic brain activity of the default mode network in Alzheimer’s disease: A resting-state fMRI study

作者：Zhengluan Liao, Wangdi Sun, Xiaozheng Liu, Zhongwei Guo, Dewang Mao, Enyan Yu, Yan Chen · 发表于：Frontiers in Human Neuroscience · 年份：2022 · DOI：10.3389/fnhum.2022.951114 · 被引用次数：10 · 研究领域：Functional Brain Connectivity Studies、Dementia and Cognitive Impairment Research、EEG and Brain-Computer Interfaces

Objective Static regional homogeneity (ReHo) based on the resting-state functional magnetic resonance imaging (rs-fMRI) has been used to study intrinsic brain activity (IBA) in Alzheimer’s disease (AD). However, few studies have examined dynamic ReHo (dReHo) in AD. In this study, we used rs-fMRI and dReHo to investigate the alterations in dynamic IBA in patients with AD to uncover dynamic imaging markers of AD. Method In total, 111 patients with AD, 29 patients with mild cognitive impairment (MCI), and 73 healthy controls (HCs) were recruited for this study ultimately. After the rs-fMRI scan, we calculated the dReHo values using the sliding window method. ANOVA and post hoc two-sample t -tests were used to detect the differences among the three groups. We used the mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) to evaluate the cognitive function of the subjects. The associations between the MMSE score, MoCA score, and dReHo were assessed by the Pearson correlation analysis. Results Significant dReHo variability in the right middle frontal gyrus (MFG) and right posterior cingulate gyrus (PCG) was detected in the three groups through ANOVA. In post hoc analysis, the AD group exhibited significantly greater dReHo variability in the right MFG than the MCI group. Compared with the HC group, the AD group exhibited significantly increased dReHo variability in the right PCG. Furthermore, dReHo variability in the right PCG was significantly negatively cor...