Ultrasound-augmented anti-inflammatory exosomes for targeted therapy in rheumatoid arthritis

作者：Yuanjiao Tang, Zihe Wu, Ruiqian Guo, Jianbo Huang, Xiao Rong, Bihui Zhu, Liyun Wang, Lang Ma, Chong Cheng, Li Qiu · 发表于：Journal of Materials Chemistry B · 年份：2022 · DOI：10.1039/d2tb01219g · 被引用次数：37 · 研究领域：Extracellular vesicles in disease、Advancements in Transdermal Drug Delivery、Photoacoustic and Ultrasonic Imaging

integrating RAW264.7 macrophage-derived exosomes and a powerful anti-inflammatory immune modulator interleukin-10 by an electroporation method. Then, non-invasive ultrasound was used to increase the permeability of blood vessels and augment the targeted accumulation of AI-Exo to inflammatory tissues, which could promote macrophage polarization to M2 phenotypes, relieve inflammation symptoms, stimulate resolution, and accelerate tissue repair against collagen-induced arthritis. This work intensely supports that ultrasound-augmented AI-Exo has significant targeted anti-inflammatory therapeutic effects, and the combined mechanism of anti-inflammation and pro-resolution gives unique insights into the treatment of not only RA but also other inflammatory diseases, which provides an effective strategy and a promising prospect for future wider biomedical applications and clinical transformations.