Epidemiological and clinical characteristics of pertussis in children and their close contacts in households: A cross-sectional survey in Zhejiang Province, China

作者：Luo-Na Lin, Jin-Si Zhou, Chun‐Zhen Hua, Guannan Bai, Yumei Mi, Ming‐Ming Zhou · 发表于：Frontiers in Pediatrics · 年份：2022 · DOI：10.3389/fped.2022.976796 · 被引用次数：24 · 研究领域：Bacterial Infections and Vaccines、Pneumonia and Respiratory Infections、Influenza Virus Research Studies

Background Despite the expanded immunization programs, the “re-emergence of pertussis” has become a global concern in recent years. At present, the prevalence of pertussis in China is seriously underestimated, and the role of close contact on the disease spreading in children remains unclear. Objectives Our study aimed to investigate pertussis’s epidemiological and clinical characteristics in children and their close contacts in households, as well as the antimicrobial resistance of Bordetella pertussis (B. pertussis) in Zhejiang Province, China. Methods We have collected the retrospective and prospective data of children who were suspected of pertussis and their close contacts in households from January 1, 2018, to December 31, 2020, in the Children’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. Nasopharyngeal swabs were collected and cultured for B. pertussis. Antibiotics susceptibility test was determined by using E-test methods. Clinical information was collected from the medical records systems. Results A total of 350 index patients and their 946 family members (close contacts in households) from 350 families were recruited. B. pertussis strains were isolated from 130 (37.1%) index patients and 116 (12.3%) close contacts. 37 index patients had negative culture results for B. pertussis while their close contacts were positive. A higher positive rate was found in female adults than that in male adults (16.3% vs. 5.1%, P < 0.01). The positive...