Recent Advances in DNA‐Based Cell Surface Engineering for Biological Applications

作者：Lexun Li, Shuang Liu, Chunjuan Zhang, Zhenzhen Guo, Shuxuan Shao, Xiaodan Deng, Qiaoling Liu · 发表于：Chemistry - A European Journal · 年份：2022 · DOI：10.1002/chem.202202070 · 被引用次数：11 · 研究领域：Advanced biosensing and bioanalysis techniques、RNA Interference and Gene Delivery、Biosensors and Analytical Detection

Due to its excellent programmability and biocompatibility, DNA molecule has unique advantages in cell surface engineering. Recent progresses provide a reliable and feasible way to engineer cell surfaces with diverse DNA molecules and DNA nanostructures. The abundant form of DNA nanostructures has greatly expanded the toolbox of DNA-based cell surface engineering and gave rise to a variety of novel and fascinating applications. In this review, we summarize recent advances in DNA-based cell surface engineering and its biological applications. We first introduce some widely used methods of immobilizing DNA molecules on cell surfaces and their application features. Then we discuss the approaches of employing DNA nanostructures and dynamic DNA nanotechnology as elements for creating functional cell surfaces. Finally, we review the extensive biological applications of DNA-based cell surface engineering and discuss the challenges and prospects of DNA-based cell surface engineering.