Suppression of Lipopolysaccharide‐Induced Sepsis by Tetrahedral Framework Nucleic Acid Loaded with Quercetin

作者：Zhiqiang Liu, Xingyu Chen, Wen‐Juan Ma, Yang Gao, Yangxue Yao, Jiajie Li, Tianxu Zhang, Xin Qin, Yichen Ge, Yueying Jiang, Yunfeng Lin · 发表于：Advanced Functional Materials · 年份：2022 · DOI：10.1002/adfm.202204587 · 被引用次数：83 · 研究领域：RNA Interference and Gene Delivery、Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics

Abstract Sepsis has affected millions of people worldwide with high mortality rate and lack of effective strategies. Previous studies have reported that quercetin (Que) can attenuate lipopolysaccharide (LPS)‐Induced sepsis. However, for poor water solubility, low bioavailability, and instability, the application of Que is limited. Hence, a nano‐system is constructed to deliver Que based on tetrahedral framework nucleic acid (tFNA), namely tFNA‐Que. For the anti‐inflammatory, anti‐oxidant, and delivery performance of tFNA, tFNA is designed as the effective carrier to deliver Que. The tFNA‐Que possesses the simple synthesis method, stable performance, good biocompatibility, favorable water solubility, excellent anti‐inflammatory, and anti‐oxidation property. As a result, tFNA‐Que can attenuate LPS‐Induced systemic inflammation and multiple organ injury of mice. In brief, the synthesis of tFNA‐Que provides a simple and effective synergistic delivery nano‐system, which may be a promising candidate for sepsis.