Steric Effects in the Deposition Mode and Drug-Delivering Efficiency of Nanocapsule-Based Multilayer Films

作者：Li Xu, Zihan Chu, Jianhua Zhang, Tingwei Cai, Xingxing Zhang, Yinzhao Li, Hailong Wang, Xiaochen Shen, Raymond Cai, Haifeng Shi, Chunyin Zhu, Jia Hong Pan, Donghui Pan · 发表于：ACS Omega · 年份：2022 · DOI：10.1021/acsomega.2c03591 · 被引用次数：181 · 研究领域：Polymer Surface Interaction Studies、Advanced Polymer Synthesis and Characterization、Dendrimers and Hyperbranched Polymers

-PDMAEMA)-by quaternization with methyl sulfate. As revealed by the data results, SNCs with coronas with higher quaternization degrees resulted in a larger layering distance of the film structure because of weaker ionic pairing (due to the presence of a bulky methyl spacer) between SNCs and PSS. Interestingly, when comparing the drug release profile of the encapsulated drugs from SNC-based films, the release rate was slower in the case of capsule coronas with higher quaternization degrees because of the larger diffusion distance of the encapsulated drugs and stronger hydrophobic-hydrophobic interactions between SNCs and drug molecules.