Prognostic Value of Right Atrial Pressure-Corrected Cardiac Power Index in Cardiogenic Shock

作者：Luca Baldetti, Matteo Pagnesi, Guglielmo Gallone, Giuseppe Barone, Nicolai Fierro, Francesco Calvo, Mario Gramegna, Vittorio Pazzanese, A Venuti, Stefania Sacchi, Gaetano Maria De Ferrari, Daniel Burkhoff, Hoong Sern Lim, Alberto Cappelletti · 发表于：ESC Heart Failure · 年份：2022 · DOI：10.1002/ehf2.14093 · 被引用次数：26 · 研究领域：Mechanical Circulatory Support Devices、Hemodynamic Monitoring and Therapy、Cardiac Arrest and Resuscitation

Abstract Aim The pulmonary artery catheter (PAC)-derived cardiac power index (CPI) has been found of prognostic value in cardiogenic shock (CS) patients. The original CPI equation included the right atrial pressure (RAP), accounting for heart filling pressure as a determinant of systolic myocardial work, but this term was subsequently omitted. We hypothesized that the original CPI formula (CPIRAP) is superior to current CPI for risk stratification in CS. Methods and results A single-centre cohort of 80 consecutive Society for Cardiovascular Angiography and Interventions (SCAI) B-D CS patients with available PAC records was included. Overall in-hospital mortality was 21.3%. Results showed CPIRAP to be the strongest haemodynamic predictor of in-hospital death (padj = 0.038), outperforming CPI [area under the receiver operating characteristic (ROC) curves: 0.726 and 0.673, P-for-difference = 0.025]. When the population was stratified according to the identified CPIRAP (0.28 W/m2) and accepted CPI (0.32 W/m2) thresholds, the cohort with discordant indexes (low CPIRAP and high CPI) comprised a group of 13 patients featuring a congested phenotype with frequent right ventricle or biventricular involvement. In this group, in-hospital mortality was high (30.8%) similar to those with concordant low CPI and CPIRAP. Conclusion Incorporating RAP in CPI calculation (CPIRAP) improves the prognostic yield in patients with CS SCAI B-D. A cut-off of 0.28 W/m2 identifies patients at higher risk...