The relationship between dyslipidemia and inflammation among adults in east coast China: A cross-sectional study

作者：Najiao Hong, Yongjun Lin, Zhirong Ye, Chunbaixue Yang, Yulong Huang, Qi Duan, Sixin Xie · 发表于：Frontiers in Immunology · 年份：2022 · DOI：10.3389/fimmu.2022.937201 · 被引用次数：90 · 研究领域：Atherosclerosis and Cardiovascular Diseases、Lipoproteins and Cardiovascular Health、Adipokines, Inflammation, and Metabolic Diseases

Objective: Dyslipidemia is one of the major public health problems in China. It is characterized by multisystem dysregulation and inflammation, and oxidant/antioxidant balance has been suggested as an important factor for its initiation and progression. The objective of this study was to determine the relationship between prevalence of dyslipidemia and measured changes in the levels of proinflammatory cytokines (IL-6, TNF-a, and MCP-1), thiobarbituric acid-reactant substances (TBARS), and serum total antioxidant capacity (TAC) in serum samples. Study design: A cross-sectional survey with a purposive sampling of 2,631 enrolled participants (age 18-85 years) was performed using the adult population of long-term residents of the municipality of east coast China in Fujian province between the years 2017 and 2019. Information on general health status, dyslipidemia prevalence, and selected mediators of inflammation was collected through a two-stage probability sampling design according to socioeconomic level, sex, and age. Methods: The lipid profile was conducted by measuring the levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) with an autoanalyzer. Dyslipidemia was defined according to National Cholesterol Education Program Adult Treatment Panel III diagnostic criteria, and patients with it were identified by means of a computerized database. Serum parameters including IL-6/TNF-a/MCP...