Copper-Catalyzed One-Step Formation of Four C–N Bonds toward Polyfunctionalized Triazoles via Multicomponent Reaction

作者：Xuelun Duan, Nan Zheng, Gongbo Liu, Ming Li, Qiming Wu, Xinhao Sun, Wangze Song · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c02273 · 被引用次数：22 · 研究领域：Click Chemistry and Applications、Chemical Synthesis and Analysis、Catalytic C–H Functionalization Methods

-azirines has been developed for the first time by the efficient formation of four C-N bonds in one step under mild conditions, rapidly preparing polyfunctionalized triazoles with molecular diversity involving three different intermediates of copper-acetylide, copper-allenylidene, and copper-vinyl nitrene. Propargylic ester is disclosed as a "three-in-one" building block possessing triplicate cycloaddition and nucleophilic and electrophilic properties, which could enable such a four-component transformation by high yields, broad substrate scope, and functionalization.