Regulatory T cells in skeletal muscle repair and regeneration: recent insights

作者：Jianhui Wu, Bowen Ren, Daochao Wang, Hui Lin · 发表于：Cell Death and Disease · 年份：2022 · DOI：10.1038/s41419-022-05142-8 · 被引用次数：84 · 研究领域：Immune Cell Function and Interaction、CAR-T cell therapy research、T-cell and B-cell Immunology

Skeletal muscle repair and regeneration after injury is a multi-stage process, involving a dynamic inflammatory microenvironment consisting of a complex network formed by the interaction of immune cells and their secreted cytokines. The homeostasis of the inflammatory microenvironment determines whether skeletal muscle repair tissues will ultimately form scar tissue or regenerative tissue. Regulatory T cells (Tregs) regulate homeostasis within the immune system and self-immune tolerance, and play a crucial role in skeletal muscle repair and regeneration. Dysregulated Tregs function leads to abnormal repair. In this review, we discuss the role and mechanisms of Tregs in skeletal muscle repair and regeneration after injury and provide new strategies for Treg immunotherapy in skeletal muscle diseases.