Effects of mild/asymptomatic COVID-19 on semen parameters and sex-related hormone levels in men: a systematic review and meta-analysis

作者：Bangwei Che, Pan Chen, Ying Yu, Wei Li, Tao Huang, Wenjun Zhang, Shenghan Xu, Jun He, Miao Liu, Kaifa Tang · 发表于：Asian Journal of Andrology · 年份：2022 · DOI：10.4103/aja202250 · 被引用次数：22 · 研究领域：COVID-19 Impact on Reproduction、COVID-19 and Mental Health、SARS-CoV-2 and COVID-19 Research

Coronavirus disease 2019 (COVID-19) has yet to be proven to alter male reproductive function, particularly in the majority of mild/asymptomatic patients. The purpose of this study was to explore whether mild/asymptomatic COVID-19 affects semen quality and sex-related hormone levels. To find suitable comparative studies, a systematic review and meta-analysis was done up to January 22, 2022, by using multiple databases (Web of Science, PubMed, and Embase). Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to identify and choose the studies. Meta-analysis was used to examine the semen parameters and sex-related hormones of mild/asymptomatic COVID-19 patients before and after infection. The effects of semen collection time, fever, and intensity of verification on semen following infection were also investigated. A total of 13 studies (n = 770) were included in the analysis, including three case-control studies, six pre-post studies, and four single-arm studies. A meta-analysis of five pre-post studies showed that after infection with COVID-19, sperm concentration ( I 2 = 0; P = 0.003), total sperm count ( I 2 = 46.3%; P = 0.043), progressive motility ( I 2 = 50.0%; P < 0.001), total sperm motility ( I 2 = 76.1%; P = 0.047), and normal sperm morphology ( I 2 = 0; P = 0.001) decreased. Simultaneously, a systematic review of 13 studies found a significant relationship between semen collection time after infection, inflammation severi...