Neuronavigated Repetitive Transcranial Stimulation Improves NeurocognitiveFunctioning in Veterans with Schizophrenia: A Possible Role ofBDNF Polymorphism

作者：Fengchun Wu, Meihong Xiu, Xiuru Su, Haixia Liu, Xuan Wang, Xiuling Pan, Xuan Zhang, Xinyan Lu, Long Zhao, Yingnan Chen, Yujie Shang · 发表于：Current Neuropharmacology · 年份：2022 · DOI：10.2174/1570159x20666220803154820 · 被引用次数：7 · 研究领域：Transcranial Magnetic Stimulation Studies、Nerve injury and regeneration、Obsessive-Compulsive Spectrum Disorders

It has been reported in the previous literatures that high-frequency (HF) neuronavigated repetitive transcranial magnetic stimulation (rTMS) may improve neurocognitive functioning in patients with schizophrenia. Nonetheless, the heterogeneity of the research findings with regards to the effectiveness of HF-rTMS on the neurocognitive functioning in patients with schizophrenia greatly hinders its clinical application. The current study was designed to determine the predictive role of BDNF variants for neurocognitive improvements after rTMS administration in veterans with schizophrenia. 109 hospitalized veterans with schizophrenia were randomly allocated to active HF-rTMS (n=63) or sham stimulation (n=46) over left DLPFC for 4 consecutive weeks. Neurocognitive functions were assessed by using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) at baseline and at the end of week 4. BDNF polymorphism was genotyped by the technicians. Compared with sham stimulation sessions, the immediate memory performance was significantly increased in active sessions after neuronavigated HF-rTMS administration. In addition, patients with the CC homozygotes demonstrated greater improvement of immediate memory after rTMS treatment, while T allele carriers showed no significant improvement in immediate memory domain relative to baseline performance of immediate memory. Our findings suggest that add-on neuronavigated HF-rTMS is beneficial on immediate memory only in patien...