An inflammation-targeted nanoparticle with bacteria forced release of polymyxin B for pneumonia therapy

作者：Peisen Zhang, Qiuhong Ouyang, Tianshu Zhai, Jing Sun, Jun Wu, Feng Qin, Ni Zhang, Saisai Yue, Xinchen Yang, Hanyi Zhang, Yi Hou, Deng Li, Fang Wang, Qingyuan Zhan, Qingsong Yu, Meng Qin, Zhihua Gan · 发表于：Nanoscale · 年份：2022 · DOI：10.1039/d2nr02026b · 被引用次数：32 · 研究领域：Inhalation and Respiratory Drug Delivery、Antimicrobial Peptides and Activities、Nanoplatforms for cancer theranostics

competitive binding with LPS. Through shielding the cationic nature of PMB, PMB-HA nanoparticles also possess outstanding biosafety performance in comparison to free PMB. It is thus believed that this smart delivery system may pave a new way for the resurrection of PMB in the future clinical treatment of bacterial inflammatory diseases.