Blood monocyte to high density lipoprotein cholesterol ratio (MHR) can be used as an independent risk factor of carotid artery plaque

作者：Jie Xi, Shasha Men, Jingzhu Nan, Qiuliang Yang, Jin Dong · 发表于：Research Square · 年份：2022 · DOI：10.21203/rs.3.rs-1893493/v1 · 研究领域：Cancer, Lipids, and Metabolism、Inflammatory Biomarkers in Disease Prognosis、Cardiovascular Disease and Adiposity

Abstract Background: Carotid plaque is a manifestation of carotid atherosclerosis,monocytes play a key role in atherosclerosis related inflammatory response ,high density lipoprotein cholesterol (HDL-C) has vascular protective effects such as anti-inflammatory, antithrombotic and anti atherosclerosis. This study is to investigate the relationships of MHR level and the incidence of carotid artery plaque. Methods: Data of physical examination personnel in the first medical center of the General Hospital of PLA from January to April in 2018 was collected and 3848 subjects were included for retrospectively analysis. Statistical analysis was performed on Spss 22.0 0 software and statistical software R and its GAM package. Results: The difference was statistically significant in levels of MHR, body mass index (BMI), high-sensitive C-reactive protein (hs-CRP), blood lipids (HDL-C, low-density lipoprotein cholesterol (LDL-C), total cholesterol(TC), triglyceride(Tg)), blood glucose(Glu), Hyperglycemic hemoglobin(HbA1c), renal function (Urea, creatinine(Crea), estimated glomerular filtration rate(eGFR), Uric acid (Ua)) in carotid plaque groups (p=0.000,respectively). No significant difference between the gender (p=0.635) and age(p=0.063) in different groups. MHR levels was positively correlated with levels of BMI (r = 0.364, P = 0.000), hs-CRP (r = 0.320, P =0.000), Tg (r = 0.417, P =0.000), Crea(r=0.323, P =0.000), eGFR(r=-0.248, P =0.000), Ua(r=0.383, P =0.000) and HbA1c (r=0.197, P ...