Prognostic signature for hepatocellular carcinoma based on 4 pyroptosis-related genes

作者：Sainan Duan, Jianying Gao, Weiming Lou, Yize Zhang, Ying Deng, Cong Wang, Haiyue Huang, Hui Xu, Sixuan Guo, Shuhui Lai, Feiyang Xi, Zhangwang Li, Libin Deng, Yuanbin Zhong · 发表于：BMC Medical Genomics · 年份：2022 · DOI：10.1186/s12920-022-01322-9 · 被引用次数：13 · 研究领域：Inflammasome and immune disorders、Ferroptosis and cancer prognosis、Inflammatory Biomarkers in Disease Prognosis

BACKGROUND: Hepatocellular carcinoma (HCC) is a cancer with a poor prognosis. Many recent studies have suggested that pyroptosis is important in tumour progression. However, the role of pyroptosis-related genes (PRGs) in HCC remains unclear. MATERIALS AND METHODS: We identified differentially expressed PRGs in tumours versus normal tissues. Through univariate, LASSO, and multivariate Cox regression analyses, a prognostic PRG signature was established. The signature effectiveness was evaluated by time-dependent receiver operating characteristic (t-ROC) curve and Kaplan-Meier (KM) survival analysis. The signature was validated in the ICGC (LIRI-JP) cohort. In addition, single-sample gene enrichment analysis (ssGSEA) showed the infiltration of major immune cell types and the activity of common immune pathways in different subgroups. RESULTS: Twenty-nine pyroptosis-related DEGs from The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) dataset were detected, and four genes (CTSV, CXCL8, MKI67 and PRF1) among them were selected to construct a prognostic signature. Then, the patients were divided into high- and low-risk groups. The pyroptosis-related signature was significantly associated with overall survival (OS). In addition, the patients in the high-risk group had lower levels of immune infiltration. CONCLUSION: The prognostic signature for HCC based on 4 pyroptosis-related genes has reliable prognostic and predictive value for HCC patients.