Increased Expression and Amplification of bla KPC-2 Contributes to Resistance to Ceftazidime/Avibactam in a Sequence Type 11 Carbapenem-Resistant Klebsiella pneumoniae Strain

作者：Xinhui Li, Jisheng Zhang, Chengru Yang, Jie Li, Jianmin Wang, Wan Huang, Lingyi Zeng, Xushan Liang, Wenzhang Long, Xiaoli Zhang · 发表于：Microbiology Spectrum · 年份：2022 · DOI：10.1128/spectrum.00955-22 · 被引用次数：20 · 研究领域：Antibiotic Resistance in Bacteria、Bacterial Identification and Susceptibility Testing、Antibiotics Pharmacokinetics and Efficacy

Klebsiella pneumoniae carbapenemase (KPC) production is the most common mechanism of K. pneumoniae resistance to carbapenems in China. Currently, CAZ/AVI is considered a potential alternative therapeutic option for infections caused by these isolates.