Prognostic value of preoperative platelet-related parameters and plasma fibrinogen in patients with non-muscle invasive bladder cancer after transurethral resection of bladder tumor

作者：Yutong Song, Junqiang Tian, Li Yang, Yunxin Zhang, Zhilong Dong, Hui Ding, Juan Wang, Yuhan Wang, Hanzhang Wang, Zhiping Wang · 发表于：Future Oncology · 年份：2022 · DOI：10.2217/fon-2022-0223 · 被引用次数：7 · 研究领域：Inflammatory Biomarkers in Disease Prognosis、Bladder and Urothelial Cancer Treatments、Urologic and reproductive health conditions

Aim: To investigate the prognostic value of preoperative mean platelet volume (MPV), MPV/lymphocyte ratio (MPVLR), MPV/platelet count ratio and plasma fibrinogen in patients with non-muscle invasive bladder cancer (NMIBC) after transurethral resection of bladder tumor (TURBT). Methods: A total of 371 patients who underwent TURBT were enrolled. The main end points were disease-free survival (DFS) and overall survival (OS). Results: MPVLR, tumor size, tumor number and pathological grade were independent risk factors for postoperative DFS. Age and pathological grade were independent risk factors for postoperative OS. Conclusion: MPVLR is an independent risk factor for DFS in NMIBC patients and could be used as a parameter to predict postoperative tumor recurrence in patients after TURBT.