Osteoarthritis and chronic pain: Interleukin-6 as a common denominator and therapeutic target

作者：Maurizio Pacifici · 发表于：Science Signaling · 年份：2022 · DOI：10.1126/scisignal.add3702 · 被引用次数：17 · 研究领域：Osteoarthritis Treatment and Mechanisms、Inflammatory mediators and NSAID effects、Bone Metabolism and Diseases

Osteoarthritis (OA) is a common and problematic disorder that is often associated with chronic pain, a combination that renders OA a leading cause of physical disability and an unmet clinical challenge. In this issue of Science Signaling , Liao et al. show that interleukin-6 is a driver of both joint tissue degradation and pain, revealing a common culprit and a possible comprehensive target of therapeutic intervention.