Clinical and Therapeutic Factors Vary by Prognosis in Patients with Pathological Complete Response After Neoadjuvant Therapy for Breast Cancer

作者：Z Huang, Sheng Jin, Miaoyu Zeng, Shu J, Liu Y, J Zhang, Xu Bo, Niu M, Sun Shu, Abiyasi Nanding, Minghui Shan, Xiaotian Li, Guitao Zhang · 发表于：DOAJ (DOAJ: Directory of Open Access Journals) · 年份：2021 · 研究领域：Endometrial and Cervical Cancer Treatments

Zhenfeng Huang,1,* Shiyang Jin,1,* Mengyao Zeng,2,* Jing Shu,1 Yang Liu,1 Jinxing Zhang,1 Bingqi Xu,1 Ming Niu,1 Shanshan Sun,1 Abiyasi Nanding,3 Xiaobo Li,3 Ming Shan,4 Guoqiang Zhang4 1Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, People’s Republic of China; 2Department of Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150081, People’s Republic of China; 3Department of Pathology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, 150081, People’s Republic of China; 4 20th Floor Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ming Shan; Guoqiang Zhang Email shanming@ems.hrbmu.edu.cn; zhangguoqiang@hrbmu.edu.cnPurpose: To determine clinical predictors of recurrence and metastasis in patients with pathological complete response (pCR) after neoadjuvant chemotherapy (NCT).Methods: Patients treated with NCT who achieved pCR (n=285) were classified into three groups according to pre-NCT clinical stage (cStage): group I (IIa–IIb), group II (IIIa), and group III (IIIb–IIIc). Survival was analysed using the Kaplan–Meier method. The relationships between clinicopathological factors and recurrence were determined using Cox regression analysis.Results: The median follow-up was 31 months. The 3-year disease-free survival and overall sur...