Intestinal Microbiota in Colorectal Adenoma-Carcinoma Sequence

作者：Hanju Hua, Yanhong Sun, Xinjue He, Yi Chen, Lisong Teng, Chao Lu · 发表于：Frontiers in Medicine · 年份：2022 · DOI：10.3389/fmed.2022.888340 · 被引用次数：59 · 研究领域：Gut microbiota and health、Colorectal Cancer Surgical Treatments、Colorectal Cancer Screening and Detection

Background Most colorectal cancer (CRC) cases are sporadic and develop along the adenoma-carcinoma sequence. Intestinal microbial dysbiosis is involved in the development of colorectal cancer. However, there are still no absolute markers predicting the progression from adenoma to carcinoma. This study aimed to investigate the characteristics of intestinal microbiota in patients with colorectal adenoma and carcinoma and its correlations with clinical characteristics. Methods Fecal samples were collected from 154 patients with CRC, 20 patients with colorectal adenoma (AD) and 199 healthy controls. To analyze the differences in the intestinal microbiota, 16S rRNA gene sequencing was conducted. Results At the genus level, there were four significantly different genera among the three groups, namely Acidaminococcus, Alloprevotella, Mycoplasma, and Sphingobacterium, while Acidaminococcus significantly decreased with the order of Control-AD-CRC ( P < 0.05). In addition, Parvimonas, Peptostreptococcus, Prevotella, Butyricimonas, Alistipes, and Odoribacter were the key genera in the network of colorectal adenoma/carcinoma-associated bacteria. The top 10 most important species, including Butyricimonas synergistica , Agrobacterium larrymoorei , Bacteroides plebeius , Lachnospiraceae bacterium feline oral taxon 001 , Clostridium scindens , Prevotella heparinolytica, bacterium LD2013 , Streptococcus mutans , Lachnospiraceae bacterium 19gly4 , and Eubacterium hallii , showed the bes...