Sticking-bacteria gel enhancing anti-multidrug-resistant microbial therapy under ultrasound

作者：Ya-Qi Zhu, Weiqiang Huang, Guang Chen, L. Xia, Ye‐Zi You, Yue Yu · 发表于：Nano Research · 年份：2022 · DOI：10.1007/s12274-022-4547-4 · 被引用次数：16 · 研究领域：Nanoplatforms for cancer theranostics、Inhalation and Respiratory Drug Delivery、Luminescence and Fluorescent Materials

The use of antibiotic could cause severe drug-resistance and the increasing spread of pathogenic drug-resistant bacteria has brought a big threat to human health, hence, some innovative methods inspired, such as sonodynamic therapy, have become increasingly attractive for realizing the antibiotic-free methods against bacterial infection. However, many pathogens can invade normal healthy cells to establish intracellular replicative niches, which makes it more difficult to kill and remove these bacteria. Herein, inspired by respiratory mucus trapping bacteria to kill them, we developed a novel gel of amorphous TiO x nanofibers dotted with Ti 2 C(OH) 2 nanosheets, which could capture and trap bacteria into the gel via a strong binding ability toward bacteria by forming a Ti—O—P bond between phosphate in the bacterial wall and Ti-OH in the gel, thereby, efficiently blocking the invasions of bacteria. Also, the gel has excellent ability for generating reactive oxygen species (ROS) under ultrasound irradiation, therefore, the bacteria in the gel could be effectively killed by the ROS produced under ultrasound irradiation. Moreover, Ti 2 C(OH) 2 in the gel was able to scavenge H 2 O 2 , and transfer it into O 2 in the infection environment, providing enough O 2 for sonodynamic therapy. The experimental results have demonstrated that the functional gel obviously accelerated the healing of multidrug-resistant microorganisms-infected wounds.