LiverScreen project: study protocol for screening for liver fibrosis in the general population in European countries

作者：Isabel Graupera, Maja Thiele, Ann T., Miquel Serra‐Burriel, Judit Pich, Núria Fabrellas, Llorenç Caballería, Robert J. de Knegt, Ivica Grgurević, Mathias Reichert, Dominique Roulot, Jörn M. Schattenberg, Juan M. Pericàs, Paolo Angeli, Emmanuel Tsochatzis, Indra Neil Guha, Montserrat Garcı́a-Retortillo, Rosa M. Morillas, Rosario Hernández, Jordi Hoyo, Matilde Fuentes, Anita Madir, Adrià Juanola, Anna Sòria, Marta Juan, Marta Carol, Alba Díaz, Sönke Detlefsen, Pere Torán‐Monserrat, Guillem Pera, Céline Fournier, Anne Llorca, Philip N. Newsome, Michael P. Manns, Harry J. de Koning, Feliu Serra-Burriel, Fernando Cucchietti, Anita Arslanow, Marko Korenjak, Laurens van Kleef, Josep Lluis Falcó, Patrick S. Kamath, Tom H. Karlsen, Laurent Castéra, Frank Lammert, Aleksander Krag, Pere Ginès, Marifé Alvarez, Peter Andersen, Paolo Angeli, Alba Ardèvol, Anita Arslanow, Luca Beggiato, Zahia Ben Abdesselam, Lucy Bennett, Bajiha Boutouria, Alessandra Brocca, M. Teresa Broquetas, Llorenç Caballería, Valeria Calvino, Judith Camacho, Aura Capdevila, Marta Carol, Laurent Castéra, Marta Cervera, Fernando Cucchietti, Anna de Fuentes, Rob de Knegt, Sönke Detlefsen, Alba Díaz, José Diéguez Bande, Vanessa Esnault, Núria Fabrellas, Josep Lluis Falcó, Rosa Fernández, Céline Fournier, Matilde Fuentes, Peter R. Galle, Edgar García, Montserrat Garcı́a-Retortillo, E.A González Garrido, Pere Ginès, Rosa Gordillo Medina, Jordi Gratacós‐Ginès, Isabel Graupera, Ivica Grgurević, Indra Neil Guha, Eva Guix, Rebecca C. Harris, Elena Hernández Boluda, Rosario Hernández-Ibañez, Jordi Hoyo, M. Arfan Ikram, Simone Incicco, Mads Israelsen, Marta Juan, Adrià Juanola, Ralf I. Kaiser, Patrick S. Kamath, Tom H. Karlsen, Maria Kjærgaard, Harry J. de Koning, Korenjak Mf, Aleksander Krag, Johanne Kragh Hansen, Marcin Krawczyk, Irina Lambert, Frank Lammert, Philippe Laboulaye, Simon Langkjær Sørensen, J. J. Laserna, Sonia Lazaro Pi, Elsa Ledain, Vincent Lévy, Vanessa Londoño, Guirec Loyer, Anne Llorca, Ann T., Anita Madir, Michael P. Manns, Denise Marshall, M. Lluïsa Martí, Sara Martínez, Ricard Martínez Sala, Roser Masa Font, Jane Møller Jensen, Rosa M. Morillas, Laura Muñoz, Ruth Nadal, Laura Napoleone, J. M. Navarrete, Philip N. Newsome, Vibeke Lehmann Nielsen, Martina Pérez, Juan Manuel Pericas Pulido, Salvatore Piano, Judit Pich, Judit Presas Escobet, Elisa Pose, Katrine Prier Lindvig, Matthias Reichert, Carlota Riba, Dominique Roulot, Ana Belén Rubio, Maria Sánchez-Morata, Jörn M. Schattenberg, Feliu Serra-Burriel, Miquel Serra‐Burriel, Louise Skovborg Just, Milan J. Sonneveld, Anna Sòria, Christiane Stern, Patricia Such, Maja Thiele, Pere Torán, Antoni Torrejón, Marta Tonon, Emmanuel Tsochatzis, Laurens van Kleef, Paulien van Wijngaarden, Vanessa Velázquez, Ana Viu, Susanne N. Weber, Tracey Wildsmith · 发表于：BMC Public Health · 年份：2022 · DOI：10.1186/s12889-022-13724-6 · 被引用次数：31 · 研究领域：Liver Disease Diagnosis and Treatment、Nutrition and Health in Aging、Body Composition Measurement Techniques

BACKGROUND: The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especially in subjects with risk factors for chronic liver disease. Nevertheless, large population-based studies with cost-effectiveness analyses are still lacking to support the widespread use of such tools. The aim of this study is to investigate whether non-invasive liver stiffness measurement in the general population is useful to identify subjects with asymptomatic, advanced chronic liver disease. METHODS: This study aims to include 30,000 subjects from eight European countries. Subjects from the general population aged ≥ 40 years without known liver disease will be invited to participate in the study either through phone calls/letters or through their primary care center. In the first study visit, subjects will undergo bloodwork as well as hepatic fat quantification and liver stiffness measurement (LSM) by vibration-controlled transient elastography. If LSM is ≥ 8 kPa and/or if ALT levels are ≥1.5 x upper limit of normal, subjects will be referred to hospital for further evaluation and consideration of liver biopsy. The primary outcome is the percentage of subjects with LSM ≥ 8kPa. In addition, a health economic evaluation will be per...