The Regulation and Characterization of Mitochondrial‐Derived Methylmalonic Acid in Mitochondrial Dysfunction and Oxidative Stress: From Basic Research to Clinical Practice

作者：Yige Liu, Shanjie Wang, Xiaoyuan Zhang, Hengxuan Cai, Jinxin Liu, Shaohong Fang, Bo Yu · 发表于：Oxidative Medicine and Cellular Longevity · 年份：2022 · DOI：10.1155/2022/7043883 · 被引用次数：45 · 研究领域：Metabolism and Genetic Disorders、Mitochondrial Function and Pathology、Folate and B Vitamins Research

Methylmalonic acid (MMA) can act as a diagnosis of hereditary methylmalonic acidemia and assess the status of vitamin B12. Moreover, as a new potential biomarker, it has been widely reported to be associated with the progression and prognosis of chronic diseases such as cardiovascular events, renal insufficiency, cognitive impairment, and cancer. MMA accumulation may cause oxidative stress and impair mitochondrial function, disrupt cellular energy metabolism, and trigger cell death. This review primarily focuses on the mechanisms and epidemiology or progression in the clinical study on MMA.