Ginseng polysaccharides: Potential antitumor agents

作者：Ruizhi Tao, Keqin Lu, Gangfan Zong, Yawen Xia, Hongkuan Han, Yang Zhao, Zhonghong Wei, Yin Lu · 发表于：Journal of Ginseng Research · 年份：2022 · DOI：10.1016/j.jgr.2022.07.002 · 被引用次数：63 · 研究领域：Ginseng Biological Effects and Applications、Pharmacological Effects of Natural Compounds、Polysaccharides and Plant Cell Walls

As a famous herbal medicine in China and Asia, ginseng (Panax ginseng C. A. Meyer) is also known as the "King of All Herbs" and has long been used in medicine and healthcare. In addition to the obvious biological activities of ginsenosides, ginseng polysaccharides (GPs) exhibit excellent antitumor, antioxidant stress, and immunomodulatory effects. In particular, GPs can exert an antitumor effect and is a potential immunomodulator. However, due to the complexity and diversity in the structures and components of GPs, their specific physicochemical properties, and underlying mechanisms remain unclear. In this article, we have summarized the factors influencing the antitumor activity of GPs and their mechanism of action, including the stimulation of the immune system, regulation of the gut microbiota, and direct action on tumor cells.