Correlation of the characteristics of symptomatic intracranial atherosclerotic plaques with stroke types and risk of stroke recurrence: a cohort study

作者：Huayun Jiang, Kaixuan Ren, Tiantian Li, Chengqun Qian, Shenchu Gong, Tianle Wang, Li Zhu · 发表于：Annals of Translational Medicine · 年份：2022 · DOI：10.21037/atm-22-2586 · 被引用次数：10 · 研究领域：Cerebrovascular and Carotid Artery Diseases、Acute Ischemic Stroke Management、Cardiovascular Health and Disease Prevention

Background: Symptomatic intracranial atherosclerotic stenosis (sICAS) patients had a higher risk of stroke recurrence, and the risk of acute ischemic stroke (AIS) was higher than transient ischemic attack (TIA).Therefore, it is important to explore the risk factors associated with sICAS clinical subtypes and the risk of stroke recurrence.The purpose of this study was to investigate the association between intracranial arterial culprit plaque characteristics with sICAS clinical subtypes and the risk of stroke recurrence.Methods: A total of 206 patients with sICAS were included.Baseline demographic data and relevant serologic indices were collected from all participants.All participants were assessed by high-resolution vessel wall imaging (HR-VWI) for culprit vessel and culprit plaque characteristics.The follow-up method was outpatient or telephone follow-up.Associated factors for sICAS clinical subtypes were analyzed by binary logistic regression.Cox proportional hazard regression analysis were used to analysis the independent risk factors for recurrent stroke.Results: In this group, there were 154 patients with AIS, 52 patients with TIA, 124 patients with anterior circulation ischemic symptom (ACiS), and 82 patients with posterior circulation ischemic symptom (PCiS).Male gender [odds ratio (OR) =5.575, 95% confidence interval (CI): 2.120 to 14.658], history of previous statin use (OR =0.309, 95% CI: 0.113 to 0.843) and serum apolipoprotein A/B values (OR =0.363, 95% CI: 0.139...