Dual-stream cortical feedbacks mediate sensory prediction

作者：Qian Chu, Ou Ma, Yuqi Hang, Xing Tian · 发表于：bioRxiv (Cold Spring Harbor Laboratory) · 年份：2022 · DOI：10.1101/2022.07.12.499695 · 被引用次数：1 · 研究领域：Neural dynamics and brain function、Neuroscience and Music Perception、Functional Brain Connectivity Studies

Abstract Predictions are constantly generated from diverse sources to optimize cognitive functions in the ever-changing environment. However, the neural origin and generation process of top-down induced prediction remain elusive. We hypothesized that motor-based and memory-based predictions are mediated by distinct feedback networks from motor and memory systems to the sensory cortices. Using fMRI and a dual imagery paradigm, we showed that motor and memory upstream systems excited the auditory cortex in a content-specific manner. Moreover, the inferior and posterior parts of the parietal lobe differentially relayed predictive signals in motor-to-sensory and memory-to-sensory networks. Our results reveal the functionally distinct neural networks that mediate top-down sensory prediction and ground the neurocomputational basis of predictive processing.