The DIRECT consortium and the REST-meta-MDD project: towards neuroimaging biomarkers of major depressive disorder

作者：Xiao Chen, Bin Lu, Huixian Li, Xueying Li, Yuwei Wang, F. Xavier Castellanos, Liping Cao, Ning-Xuan Chen, Wei Chen, Yuqi Cheng, Shi‐Xian Cui, Zhao‐Yu Deng, Yiru Fang, Qiyong Gong, Wenbin Guo, Zheng-Jia-Yi Hu, Li Kuang, Baojuan Li, Le Li, Tao Li, Tao Lian, Yi‐Fan Liao, Yan‐Song Liu, Zhening Liu, Jianping Lu, Qinghua Luo, Huaqing Meng, Daihui Peng, Jiang Qiu, Yuedi Shen, Tianmei Si, Yanqing Tang, Chuanyue Wang, Fei Wang, Huaning Wang, Kai Wang, Xiang Wang, Ying Wang, Zihan Wang, Xiaoping Wu, Chunming Xie, Guangrong Xie, Peng Xie, Xiufeng Xu, Hong Yang, Jian Yang, Shuqiao Yao, Yongqiang Yu, Yonggui Yuan, Kerang Zhang, Wei Zhang, Zhijun Zhang, Jun‐Juan Zhu, Xi‐Nian Zuo, Jingping Zhao, Yu‐Feng Zang, Chao‐Gan Yan, Xiao Chen, Liping Cao, Wei Chen, Yuqi Cheng, Yiru Fang, Qiyong Gong, Wenbin Guo, Li Kuang, Baojuan Li, Tao Li, Yan‐Song Liu, Zhening Liu, Jianping Lu, Qinghua Luo, Huaqing Meng, Daihui Peng, Jiang Qiu, Yuedi Shen, Tianmei Si, Yanqing Tang, Chuanyue Wang, Fei Wang, Huaning Wang, Kai Wang, Xiang Wang, Ying Wang, Xiaoping Wu, Chunming Xie, Guangrong Xie, Peng Xie, Xiufeng Xu, Hong Yang, Jian Yang, Shuqiao Yao, Yongqiang Yu, Yonggui Yuan, Kerang Zhang, Wei Zhang, Zhijun Zhang, Jun‐Juan Zhu, Xi‐Nian Zuo, Jingping Zhao, Yu‐Feng Zang, Chao‐Gan Yan · 发表于：Psychoradiology · 年份：2022 · DOI：10.1093/psyrad/kkac005 · 被引用次数：128 · 研究领域：Functional Brain Connectivity Studies、Advanced Neuroimaging Techniques and Applications、Advanced MRI Techniques and Applications

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder (MDD), reproducible findings are lacking, probably reflecting mostly small sample sizes and heterogeneity in analytic approaches. To address these issues, the Depression Imaging REsearch ConsorTium (DIRECT) was launched. The REST-meta-MDD project, pooling 2428 functional brain images processed with a standardized pipeline across all participating sites, has been the first effort from DIRECT. In this review, we present an overview of the motivations, rationale, and principal findings of the studies so far from the REST-meta-MDD project. Findings from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network, in whole-brain topological properties, in dynamic features, and in functional lateralization. These well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven research. Following these fruitful explorations, DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations. A state-of-the-art, surface-based preprocessing pipeline has also been introduced to improve sensitivity. Functional images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique...