Accessing chiral 2,2-disubstituted morpholines via organocatalytic enantioselective chlorocycloetherification

作者：Haijing Zhong, Tengbo Ding, Qifeng Guo, Tian Zeng, Pei Yu, Xiaojian Jiang · 发表于：Organic Chemistry Frontiers · 年份：2022 · DOI：10.1039/d2qo00390b · 被引用次数：6 · 研究领域：Vanadium and Halogenation Chemistry、Fluorine in Organic Chemistry、Catalytic C–H Functionalization Methods

A catalytic asymmetric halocycloetherification process is developed to achieve enantioenriched quaternary 2,2-disubstituted morpholines using an organo-catalyst.