Quantification of aneurysm wall enhancement in intracranial fusiform aneurysms and related predictors based on high-resolution magnetic resonance imaging: a validation study

作者：Fei Peng, Mingzhu Fu, Jiaxiang Xia, Hao Niu, Lang Liu, Xin Feng, Peng Xu, Xiaoyan Bai, Zhiye Li, Jigang Chen, Xin Tong, Xiaoxin He, Boya Xu, Xuge Chen, Hongyi Liu, Binbin Sui, Yonghong Duan, Rui Li, Aihua Liu · 发表于：Therapeutic Advances in Neurological Disorders · 年份：2022 · DOI：10.1177/17562864221105342 · 被引用次数：15 · 研究领域：Intracranial Aneurysms: Treatment and Complications、Meningioma and schwannoma management、Vascular Malformations Diagnosis and Treatment

Background: Aneurysm wall enhancement (AWE) in high-resolution magnetic resonance imaging (HR-MRI) has emerged as a new imaging biomarker of intracranial aneurysm instability. Objective: To determine a standard method of AWE quantification for predicting fusiform intracranial aneurysms (FIAs) stability by comparing the sensitivity of each parameter in identifying symptomatic FIAs. The predictors of AWE and FIA types were also identified. Methods: We retrospectively analyzed consecutive fusiform aneurysm patients who underwent HR-MRI from two centers. The aneurysm-to-pituitary stalk contrast ratio (CR stalk ), aneurysm enhancement ratio, and aneurysm enhancement index were extracted, and their sensitivities in discriminating aneurysm symptoms were compared using the receiver-operating characteristic curve. Morphological parameters of fusiform aneurysm were extracted based on 3D vessel model. Uni- and multivariate analyses of related predictors for AWE, CR stalk , and FIA types were performed, respectively. Results: Overall, 117 patients (mean age, 53.3 ± 11.7 years; male, 75.2%) with 117 FIAs underwent HR-MRI were included. CR stalk with the maximum signal intensity (CR stalk-max ) had the highest sensitivity in identifying symptomatic FIAs with an area under the curve value (0.697) and a cut-off value of 0.90. The independent predictors of AWE were aneurysm symptoms [(odds ratio) OR = 3.754, p = 0.003], aspirin use (OR = 0.248, p = 0.037), and the maximum diameter of the cros...