Mitochondrial Dysfunction and Chronic Liver Disease

作者：Chunyan Zhang, Yabin Zhao, Mengli Yu, Jianru Qin, Bingyu Ye, Qiwen Wang · 发表于：Current Issues in Molecular Biology · 年份：2022 · DOI：10.3390/cimb44070218 · 被引用次数：67 · 研究领域：Liver Disease Diagnosis and Treatment、Metabolism and Genetic Disorders、Mitochondrial Function and Pathology

Mitochondria are generally considered the powerhouse of the cell, a small subcellular organelle that produces most of the cellular energy in the form of adenosine triphosphate (ATP). In addition, mitochondria are involved in various biological functions, such as biosynthesis, lipid metabolism, oxidative phosphorylation, cell signal transduction, and apoptosis. Mitochondrial dysfunction is manifested in different aspects, like increased mitochondrial reactive oxygen species (ROS), mitochondrial DNA (mtDNA) damage, adenosine triphosphate (ATP) synthesis disorder, abnormal mitophagy, as well as changes in mitochondrial morphology and structure. Mitochondrial dysfunction is related to the occurrence and development of various chronic liver diseases, including hepatocellular carcinoma (HCC), viral hepatitis, drug-induced liver injury (DILI), alcoholic fatty liver (AFL), and non-alcoholic fatty liver (NAFL). In this review, we summarize and discuss the role and mechanisms of mitochondrial dysfunction in chronic liver disease, focusing on and discussing some of the latest studies on mitochondria and chronic liver disease.