Gold nanocluster adjuvant enables the eradication of persister cells by antibiotics and abolishes the emergence of resistance

作者：Zhixin Cao, Xiaohua Chen, Jing Chen, Anping Xia, Brian Bacacao, Jessica Tran, Devesh Sharma, L. Bekale, Peter L. Santa Maria · 发表于：Nanoscale · 年份：2022 · DOI：10.1039/d2nr01003h · 被引用次数：25 · 研究领域：Cystic Fibrosis Research Advances、Antibiotic Resistance in Bacteria、Bacterial biofilms and quorum sensing

infection was observed when combining antibiotics and AuNC@CPP, informing a potential approach to improve the treatment of CSOM. We established that the mechanism of action of AuNC@CPP is due to disruption of the proton gradient and membrane hyperpolarization. The method presented here could compensate for the lack of new antibiotics to combat persister cells. This method could also benefit the current effort to slow resistance development because AuNC@CPP abolished the emergence of drug-resistant strains induced by antibiotics.