Preliminary Study of Genome-Wide Association Identified Novel Susceptibility Genes for Hemorheological Indexes in a Chinese Population

作者：Yuxiao Sun, Zhaoyun Cheng, Zhiping Guo, Guoyou Dai, Yongqiang Li, Yan Chen, Ruigang Xie, Xianqing Wang, Mingxia Cui, Guoqing Lu, Aifeng Wang, Chuanyu Gao · 发表于：Transfusion Medicine and Hemotherapy · 年份：2022 · DOI：10.1159/000524849 · 被引用次数：5 · 研究领域：Blood properties and coagulation、Genetic Associations and Epidemiology、Myeloproliferative Neoplasms: Diagnosis and Treatment

Background: Genome-wide association studies for various hemorheological characteristics have not been reported. We aimed to identify genetic loci associated with hemorheological indexes in a cohort of healthy Chinese Han individuals. Methods: Genotyping was performed using Applied Biosystems Axiom™ Precision Medicine Diversity Array in 838 individuals, and 6,423,076 single nucleotide polymorphisms were available for genotyping. The relations were examined in an additive genetic model using mixed linear regression and combined with identical by descent matrix. Results: We identified 38 genetic loci (p &#x3c; 5 × 10−6) related to hemorheological traits. In which, LOC102724502-OLIG2 rs28371438 was related to the levels of nd30 (p = 8.58 × 10−07), nd300 (p = 1.89 × 10−06), erythrocyte rigidity (p = 1.29 × 10−06), assigned viscosity (p = 6.20 × 10−08) and whole blood high cut relative (p = 7.30 × 10−08). The association of STK32B rs4689231 for nd30 (p = 3.85 × 10−06) and nd300 (p = 2.94 × 10...