Effect of Electroacupuncture on Insomnia in Patients With Depression

作者：Xuan Yin, Wei Li, Tingting Liang, Bing Lu, Hongyu Yue, Shanshan Li, Victor W. Zhong, Wei Zhang, Xia Li, Shuang Zhou, Yiqun Mi, Huangan Wu, Shifen Xu · 发表于：JAMA Network Open · 年份：2022 · DOI：10.1001/jamanetworkopen.2022.20563 · 被引用次数：161 · 研究领域：Sleep and related disorders、Acupuncture Treatment Research Studies、Traditional Chinese Medicine Studies

Importance: Electroacupuncture (EA) is a widely recognized therapy for depression and sleep disorders in clinical practice, but its efficacy in the treatment of comorbid insomnia and depression remains uncertain. Objective: To assess the efficacy and safety of EA as an alternative therapy in improving sleep quality and mental state for patients with insomnia and depression. Design, Setting, and Participants: A 32-week patient- and assessor-blinded, randomized, sham-controlled clinical trial (8-week intervention plus 24-week observational follow-up) was conducted from September 1, 2016, to July 30, 2019, at 3 tertiary hospitals in Shanghai, China. Patients were randomized to receive EA treatment and standard care, sham acupuncture (SA) treatment and standard care, or standard care only as control. Patients were 18 to 70 years of age, had insomnia, and met the criteria for depression as classified in the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition). Data were analyzed from May 4 to September 13, 2020. Interventions: All patients in the 3 groups were provided with standard care guided by psychiatrists. Patients in the EA and SA groups received real or sham acupuncture treatment, 3 sessions per week for 8 weeks, for a total of 24 sessions. Main Outcomes and Measures: The primary outcome was change in Pittsburgh Sleep Quality Index (PSQI) from baseline to week 8. Secondary outcomes included PSQI at 12, 20, and 32 weeks of follow-up; sleep parameters record...