Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children

作者：Vishal Midya, Elena Colicino, David V. Conti, Kiros Berhane, Erika Garcia, Nikos Stratakis, Sandra Andrušaitytė, Xavier Basagaña, Maribel Casas, Serena Fossati, Regina Gražulevičienė, Line Småstuen Haug, Barbara Heude, Léa Maître, Rosemary McEachan, Eleni Papadopoulou, Theano Roumeliotaki, Claire Philippat, Cathrine Thomsen, José Urquiza, Marina Vafeiadi, Nerea Varo, Miriam B. Vos, John Wright, Rob McConnell, Martine Vrijheid, Lida Chatzi, Damaskini Valvi · 发表于：JAMA Network Open · 年份：2022 · DOI：10.1001/jamanetworkopen.2022.20176 · 被引用次数：101 · 研究领域：Effects and risks of endocrine disrupting chemicals、Toxic Organic Pollutants Impact、Per- and polyfluoroalkyl substances research

Importance: Prenatal exposures to endocrine-disrupting chemicals (EDCs) may increase the risk for liver injury in children; however, human evidence is scarce, and previous studies have not considered potential EDC-mixture effects. Furthermore, the association between prenatal EDC exposure and hepatocellular apoptosis in children has not been studied previously. Objective: To investigate associations of prenatal exposure to EDC mixtures with liver injury risk and hepatocellular apoptosis in childhood. Design, Setting, and Participants: This prospective cohort study used data collected from April 1, 2003, to February 26, 2016, from mother-child pairs from the Human Early-Life Exposome project, a collaborative network of 6 ongoing, population-based prospective birth cohort studies from 6 European countries (France, Greece, Lithuania, Norway, Spain, and the UK). Data were analyzed from April 1, 2021, to January 31, 2022. Exposures: Three organochlorine pesticides, 5 polychlorinated biphenyls, 2 polybrominated diphenyl ethers (PBDEs), 3 phenols, 4 parabens, 10 phthalates, 4 organophosphate pesticides, 5 perfluoroalkyl substances, and 9 metals. Main Outcomes and Measures: Child serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), and CK-18 were measured at 6 to 11 years of age. Risk for liver injury was defined as having ALT, AST, and/or GGT levels above the 90th percentile. Associations of liver injury or cytokeratin 18 (CK...