Aptamer-Based Sensors for Thrombin Detection Application

作者：Hongzhi Sun, Nannan Wang, Lin Zhang, Hong‐Min Meng, Zhaohui Li · 发表于：Chemosensors · 年份：2022 · DOI：10.3390/chemosensors10070255 · 被引用次数：26 · 研究领域：Advanced biosensing and bioanalysis techniques、RNA Interference and Gene Delivery、Blood Coagulation and Thrombosis Mechanisms

Thrombin facilitates the aggregation of platelet in hemostatic processes and participates in the regulation of cell signaling. Therefore, the development of thrombin sensors is conducive to comprehending the role of thrombin in the course of a disease. Biosensors based on aptamers screened by SELEX have exhibited superiority for thrombin detection. In this review, we summarized the aptamer-based sensors for thrombin detection which rely on the specific recognitions between thrombin and aptamer. Meanwhile, the unique advantages of different sensors including optical and electrochemical sensors were also highlighted. Especially, these sensors based on electrochemistry have the potential to be miniaturized, and thus have gained comprehensive attention. Furthermore, concerns about aptamer-based sensors for thrombin detection, prospects of the future and promising avenues in this field were also presented.