Correlation analysis of the triglyceride glucose index and heart failure with preserved ejection fraction in essential hypertensive patients

作者：Li ping Liao, Yang Yang, Yilin Wu, Weizhen Li · 发表于：Clinical Cardiology · 年份：2022 · DOI：10.1002/clc.23881 · 被引用次数：22 · 研究领域：Cardiovascular Function and Risk Factors、Diabetes, Cardiovascular Risks, and Lipoproteins、Blood Pressure and Hypertension Studies

BACKGROUND: Triglyceride glucose index (TyG index) is a novel marker of insulin resistance. Studies have shown that TyG index is closely associated with the occurrence of hypertension and cardiovascular disease. However, little is known about the correlation between TyG index and the occurrence of heart failure with preserved ejection fraction (HFpEF) in hypertensive patients. HYPOTHESIS: Our study assumes that TyG index strongly correlates with occurence of HFpEF in hypertensive patients. METHODS: This research enrolled 559 hypertensive patients (273 patients with HFpEF and 286 without HFpEF) admitted to the Department of Cardiology of Jiading Branch of Shanghai General Hospital from 2020 to 2021 as the study subjects. Gender, age, diastolic blood pressure, systolic blood pressure (SBP), and heart rate (HR) were recorded at admission. Medication history and fasting blood samples were harvested after admission to detect laboratory index. Cardiac function and ventricular structure index were measured by echocardiography. Pearson correlation analysis was conducted to identify the correlation of TyG index with cardiac function and ventricular structure. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic value of TyG index in HFpEF with hypertension. RESULTS: HFpEF patients had higher diuretic use frequencies, fasting plasma glucose, NT-proBNP, triglycerides, TyG index, left atrial diameter (LAD), left ventricular mass index (LVMI), the ratio of...