Association Between Sleep Traits and Rheumatoid Arthritis: A Mendelian Randomization Study

作者：Ruichen Gao, Ni Sang, Cheng-Zhen Jia, Meng-Yao Zhang, Bohan Li, Meng Wei, Guo‐Cui Wu · 发表于：Frontiers in Public Health · 年份：2022 · DOI：10.3389/fpubh.2022.940161 · 被引用次数：76 · 研究领域：Immune Cell Function and Interaction、Autoimmune and Inflammatory Disorders Research、Genetic Associations and Epidemiology

Currently, the causal association between sleep disorders and rheumatoid arthritis (RA) has been poorly understood. In this two-sample Mendelian randomization (TSMR) study, we tried to explore whether sleep disorders are causally associated with RA. Seven sleep-related traits were chosen from the published Genome-Wide Association Study (GWAS): short sleep duration, frequent insomnia, any insomnia, sleep duration, getting up, morningness (early-to-bed/up habit), and snoring, 27, 53, 57, 57, 70, 274, and 42 individual single-nucleotide polymorphisms (SNPs) ( P < 5 × 10 −8 ) were obtained as instrumental variables (IVs) for these sleep-related traits. Outcome variables were obtained from a public GWAS study that included 14,361 cases and 43,923 European Ancestry controls. The causal relationship between sleep disturbances and RA risk were evaluated by a two-sample Mendelian randomization (MR) analysis using inverse variance weighted (IVW), MR-Egger regression, weighted median, and weight mode methods. MR-Egger Regression and Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO) were used to test for horizontal pleomorphism and outliers. There was no evidence of a link between RA and frequent insomnia (IVW, odds ratio (OR): 0.99; 95% interval (CI): 0.84–1.16; P = 0.858), any insomnia (IVW, OR: 1.09; 95% CI: 0.85–1.42; P = 0.489), sleep duration (IVW, OR: 0.65, 95% CI: 0.38–1.10, P = 0.269), getting up (IVW, OR: 0.56, 95% CI: 0.13–2.46, P = 0.442), morning...