Polyphenol–Metal Functionalized Hydrogel Dressing with Sustained Release, Antibacterial, and Antioxidant Properties for the Potential Treatment of Chronic Wounds

作者：Zhiwen Zeng, Cuiping Guo, Daohuan Lu, Zhijie Geng, Dating Pei, Shan Yu · 发表于：Macromolecular Materials and Engineering · 年份：2022 · DOI：10.1002/mame.202200262 · 被引用次数：29 · 研究领域：Wound Healing and Treatments、Surgical Sutures and Adhesives、Silk-based biomaterials and applications

Abstract Infection and chronic inflammation caused by oxidative stress are the main challenges in chronic wound healing. In this study, a silk fibroin/kappa‐carrageenan ( k CA)‐based hydrogel functionalized with epigallocatechin‐3‐gallate (EGCG) and Cu 2+ is fabricated for chronic wound healing. Polyphenol–metal functional complexes and ionic‐covalent entanglement networks are prepared by introducing Cu 2+ . Cu 2+ coordinates with k CA to enhance the mechanical properties and chelates with EGCG to form an EGCG‐Cu 2+ complex that continuously releases EGCG. The sustained release of EGCG enhances the antibacterial properties by synergizing with the effects of Cu 2+ . Furthermore, the prepared hydrogel exhibits a potent ability to scavenge excessive intracellular reactive oxygen species, controllable antioxidant bioactivity, and reliable biocompatibility. Ultimately, the resulting multifunctional hydrogel dressing provides a potential and effective strategy for chronic wound care management with increased mechanical strength and antibacterial and antioxidant properties.