Clinicopathological characteristics and prognostic significance of HDAC11 protein expression in non-small cell lung cancer: a retrospective study

作者：Di Lu, Zhiqiang Ma, Di Huang, Jundong Zhang, Jinfeng Li, Peng Zhi, Lizhong Zhang, Yingtong Feng, Xiangwei Ge, Jinzhao Zhai, Menglong Jiang, Xin Zhou, Charles B. Simone, Joel W. Neal, Shruti Patel, Xiaolong Yan, Yi Hu, Jinliang Wang · 发表于：Translational Lung Cancer Research · 年份：2022 · DOI：10.21037/tlcr-22-403 · 被引用次数：9 · 研究领域：Histone Deacetylase Inhibitors Research、Peptidase Inhibition and Analysis、Cancer Mechanisms and Therapy

Background: Although the prognosis of non-small cell lung cancer (NSCLC) can be assessed based on pathological type, disease stage and inflammatory indicators, the prognostic scoring model of NSCLC still needs to improve. HDAC11 is associated with poor prognosis of partial tumors, but its prognostic relationship with NSCLC is poorly understood. In this study, the role of HDAC11 in NSCLC was studied to evaluate relationship with disease prognosis and potential therapeutic target. Methods: The clinicopathological and paracancerous tissues of patients with NSCLC primarily diagnosed in Tangdu Hospital from 2009 to 2013 were collected. Follow-up of patients were made every three months and the last follow-up period was December 2018. The expression of HDAC11 was assessed by immunohistochemistry (IHC). Then, weighted gene co-expression network analysis (WGCNA) was used to analyze the relationship between HDAC11 expression and the prognosis of lung adenocarcinoma (LUAD) patients. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Kaplan-Meier plotter database was used to verify the connection between hub genes and tumor stage and prognosis. We accessed the relationship between HDAC11 expression and clinicopathological features, and impact on the prognosis. Results: The study assessed 326 patients with NSCLC. Compared with adjacent tissues, HDAC11 expression was upregulated (HR =1.503, 95% CI: 1.172 to 1.927, P=0.001). Kaplan-Meier surv...