Co-stimulatory molecule clusters correlate with survival, immune infiltration, and tumor mutation burden in non-small cell lung cancer

作者：Chunxiao Wu, Qiquan Yu, Weizhen Shou, Kun Zhang, Yang Li, Wentao Guo, Qi Bao · 发表于：All Life · 年份：2022 · DOI：10.1080/26895293.2022.2085814 · 被引用次数：1 · 研究领域：Cancer Immunotherapy and Biomarkers、Ferroptosis and cancer prognosis、Immune cells in cancer

We aimed to identify co-stimulatory molecule clusters and explore their associations with immune infiltration and tumor mutation burden (TMB) in non-small cell lung cancer (NSCLC), using a systematic analysis based on RNA-seq and mutation data in TCGA database. Twelve immune-related prognostic co-stimulatory molecules were screened. Based on the expression of these molecules, all samples were divided into four clusters by Consensus clustering analysis. Clusters 2 and 4 were associated with worse survival and favorable prognosis, respectively. The proportion of patients with different age, Pathologic T and Pathologic stage among these four clusters showed significant differences. Cluster 4 was associated with a higher proportion of patients with pathological N0 and T1–2, as well as early tumors (stages I–II). Additionally, these clusters significantly differed in terms of immune infiltration of memory B cells, regulatory T cells, M2 macrophages, and activated memory CD4+ T cells, as well as the expression of six checkpoint genes. Worse survival was associated with a high rather than a low TMB; among the clusters, clusters 4 and 2 had the lowest and highest TMB, respectively. In conclusion, four co-stimulatory molecule clusters identified in NSCLC significantly differed in terms of survival, tumor stage, immune response, and TMB.Highlights Four co-stimulatory molecule clusters were identified that correlated differently with survival.Feature genes of four clusters were enriched...