Risk Factors for Cardiac Complications in Patients With Pheochromocytoma and Paraganglioma: A Retrospective Single-Center Study

作者：Lin Zhao, Xu Meng, QiMin Mei, Hua Fan, YeCheng Liu, Xian‐Liang Zhou, Huadong Zhu, Shuyang Zhang · 发表于：Frontiers in Endocrinology · 年份：2022 · DOI：10.3389/fendo.2022.877341 · 被引用次数：11 · 研究领域：Adrenal and Paraganglionic Tumors、Hormonal Regulation and Hypertension、Cardiac tumors and thrombi

Background Catecholamine excess arising from pheochromocytomas and paragangliomas (PPGLs) can cause a wide spectrum of cardiac manifestations. Although there are reviews of reported cases, these reviews lack detailed data, which makes it impossible to perform an accurate analysis. In this study, we conducted a comprehensive analysis of cardiovascular complications (CCs), including PPGL-related myocardial injury, cardiogenic shock, and arrhythmias requiring antiarrhythmic therapy, in a large cohort of patients with PPGL. Methods We retrospectively analyzed the clinical data of consecutive patients with PPGL admitted between January 2018 and June 2020. The prevalence and the characteristics of patients with CCs were investigated. Moreover, comparisons were made between patients with and without CCs. Results Compared with the non-CC group, the percentage of men was significantly lower (14/41 vs.92/175, 34.1% vs. 52.6%, p = 0.034) and the proportion of patients with paroxysmal hypertension was significantly higher (13/41 vs.29/173, 31.7% vs.16.8%, p = 0.03) in the CC group. More patients showed excessive sweating (19/41 vs 64/175, 46.3% vs. 24.0%, p = 0.004) and PPGL crisis (7/41 vs. 10/175, 17.1% vs.5.7%, p=0.035) in the CC group. In terms of laboratory findings, higher white blood cell [7.36 (6.49, 20.23) vs. 5.95 (5.1, 6.97)×10 9 /L, p<0.001] and platelet [339.28 ± 108.54 vs. 250.66 ± 70.83(×10 9 /L), p = 0.021] counts were more common in the CC group. There was also a ...