The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Lymphoid Neoplasms

作者：Rita Alaggio, Catalina Amador, Ioannis Anagnostopoulos, Ayoma D. Attygalle, Iguaracyra Araújo, Emilio Berti, Govind Bhagat, Anita Maria Borges, Daniel F. Boyer, Maria Calaminici, Amy Chadburn, John K. C. Chan, Wah Cheuk, Wee Joo Chng, John Kim Choi, Shih‐Sung Chuang, Sarah E. Coupland, Magdalena Czader, Sandeep S. Davé, Daphne de Jong, Ming‐Qing Du, Kojo S.J. Elenitoba‐Johnson, Judith A. Ferry, Julia Turbiner Geyer, Dita A. Gratzinger, Joan Guitart, Sumeet Gujral, Marian H. Harris, Christine J. Harrison, Sylvia Hartmann, Andreas Hochhaus, Patty M. Jansen, Kennosuke Karube, Werner Kempf, Joseph David Khoury, Hiroshi Kimura, Wolfram Klapper, Alexandra E. Kovach, Shaji Kunnathu Kumar, Alexander J. Lazar, Stefano Lazzi, Lorenzo Leoncini, Nelson Leung, Vasiliki Leventaki, Xiao‐Qiu Li, Megan S. Lim, Weiping Liu, Abner Louissaint, Andrea N. Marcogliese, L. Jeffrey Medeiros, Michael Michal, Roberto N. Miranda, Christina Mitteldorf, Santiago Montes‐Moreno, William George Morice, Valentina Nardi, Kikkeri N. Naresh, Yasodha Natkunam, Siok‐Bian Ng, Ilske Oschlies, German Ott, Marie Parrens, Melissa P. Pulitzer, S. Vincent Rajkumar, Andy C. Rawstron, Karen L. Rech, Andreas Rosenwald, JONATHAN W. SAID, Clémentine Sarkozy, Shahin Sayed, Caner Saygin, Anna Schuh, William A. Sewell, Reiner Siebert, Aliyah R. Sohani, Reuben M. Tooze, Alexandra Traverse‐Glehen, Francisco Vega, Béatrice Vergier, Ashutosh D. Wechalekar, Brent Lee Wood, Luc Xerri, Wenbin Xiao · 发表于：Leukemia · 年份：2022 · DOI：10.1038/s41375-022-01620-2 · 被引用次数：4010 · 研究领域：Lymphoma Diagnosis and Treatment、Viral-associated cancers and disorders、Chronic Lymphocytic Leukemia Research

Abstract We herein present an overview of the upcoming 5 th edition of the World Health Organization Classification of Haematolymphoid Tumours focussing on lymphoid neoplasms. Myeloid and histiocytic neoplasms will be presented in a separate accompanying article. Besides listing the entities of the classification, we highlight and explain changes from the revised 4 th edition. These include reorganization of entities by a hierarchical system as is adopted throughout the 5 th edition of the WHO classification of tumours of all organ systems, modification of nomenclature for some entities, revision of diagnostic criteria or subtypes, deletion of certain entities, and introduction of new entities, as well as inclusion of tumour-like lesions, mesenchymal lesions specific to lymph node and spleen, and germline predisposition syndromes associated with the lymphoid neoplasms.