Streptobacillus moniliformis Bacteremia in a Patient with Reactive Arthritis Without a Bite: A Case Report

作者：Junwei Huang, Xiaoyun Shan, Liuqing Wang, Xuelian Hong, Yijun Zhu, Yongjun Ma · 发表于：Jundishapur Journal of Microbiology · 年份：2022 · DOI：10.5812/jjm-126419 · 被引用次数：2 · 研究领域：Rabies epidemiology and control、Yersinia bacterium, plague, ectoparasites research、Streptococcal Infections and Treatments

Introduction: Clinically, rat bite fever (RBF) is a condition caused by Spirillum minus or Streptobacillus moniliformis infections, following rat or any rodent bite. In the absence of a rat bite, this condition cannot be accurately diagnosed. Here, we report the first case of RBF due to S. moniliformis but without a rat bite in China. Case Presentation: A 77-year-old woman with reactive arthritis was admitted to the hospital due to high fever. Initially, we suspected reactive arthritis with liver function deterioration. However, we isolated a bacterium which was confirmed to be S. moniliformis using Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Subsequently, the patient was given targeted anti-infective treatment, which completely resolved the symptoms. The patient was discharged upon fully recovery. Conclusions: Rat bite fever infection caused by S. moniliformis may occur without actual rodent bite. MALDI-TOF MS may be applied to determine the diagnosis of RBF. Difficulties in pathogen and clinical diagnosis highlight the need for discovering the complete exposure history and a greater understanding of this rare zoonotic infections.