Normobaric Hyperoxia Combined With Endovascular Treatment for Patients With Acute Ischemic Stroke

作者：Weili Li, Zhifeng Qi, Qingfeng Ma, Jiayue Ding, Chuanjie Wu, Haiqing Song, Qi Yang, Jiangang Duan, Lan Liu, Huining Kang, Longfei Wu, Kangxiang Ji, Wenbo Zhao, Chuanhui Li, Chenghe Sun, Na Li, Marc Fisher, Xunming Ji, Ke Jian Liu · 发表于：Neurology · 年份：2022 · DOI：10.1212/wnl.0000000000200775 · 被引用次数：51 · 研究领域：Acute Ischemic Stroke Management、Cardiovascular and Diving-Related Complications、Stroke Rehabilitation and Recovery

Background and Objectives To investigate the safety and efficacy of normobaric hyperoxia (NBO) combined with endovascular treatment (EVT) in patients with acute ischemic stroke (AIS). Methods In this single-center, proof-of-concept, assessor-blinded, randomized, controlled pilot study, patients with AIS in the acute anterior circulation with large vessel occlusion who had an indication for EVT were randomly assigned to the EVT group or the NBO + EVT group. The NBO + EVT group was given 100% oxygen through a face mask initiated before vascular recanalization (10L/min for 4 hours), while the EVT group was given room air. The primary endpoint was infarct volume measured by MRI within 24–48 hours after randomization. Results A total of 231 patients were screened, and 86 patients were randomized into a ratio of 1:1 (EVT group, n = 43; NBO + EVT group, n = 43). The median infarction volume of the NBO + EVT group at 24–48 hours after randomization was significantly smaller than that of the EVT group (median 20.1 vs 37.7 mL, p < 0.01). The median mRS score at 90 days was 2 for the NBO + EVT group when compared with 3 for the EVT group (adjusted value 1.8, 95% CI 1.3–4.2; p = 0.038). Compared with the EVT group, the NBO + EVT group had a lower incidence of symptomatic intracranial hemorrhagic (7% vs 12%), mortality (9% vs 16%), and adverse events (33% vs 42%); however, such a difference was not statistically significant. Discussion NBO in combination with EVT seems to be...