Copper-Catalyzed 6- endo - dig Cyclization–Coupling of 2-Bromoaryl Ketones and Terminal Alkynes toward Naphthyl Aryl Ethers in Water

作者：Lebin Su, Shimin Xie, Jianyu Dong, Neng Pan, Shuang‐Feng Yin, Yongbo Zhou · 发表于：Organic Letters · 年份：2022 · DOI：10.1021/acs.orglett.2c01654 · 被引用次数：9 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Asymmetric Hydrogenation and Catalysis

The cyclization–coupling reaction of 2-bromoaryl ketones and terminal alkynes is first realized by copper catalysis, which produces polyfunctional naphthyl aryl ethers in moderate to excellent yields with broad substrate scope and good functional group tolerance. This reaction proceeds via 6- endo - dig cyclization and C(sp 2 )–O coupling using green H 2 O as the unique solvent and 5-bromopyrimidin-2-amine as the critical additive. Mechanistically, a unique Cu(III)-acetylide probably is the key intermediate, which allows exclusive 6- endo - dig selectivity.