Risk Factors and Incidence of Epilepsy after Severe Traumatic Brain Injury

作者：Matthew Pease, Jorge González-Martínez, Ava M. Puccio, Enyinna L. Nwachuku, James F. Castellano, David O. Okonkwo, Jonathan Elmer · 发表于：Annals of Neurology · 年份：2022 · DOI：10.1002/ana.26443 · 被引用次数：66 · 研究领域：Epilepsy research and treatment、Traumatic Brain Injury and Neurovascular Disturbances、Pharmacological Effects and Toxicity Studies

We determined the incidence of post-traumatic epilepsy after severe traumatic brain injury. Of 392 patients surviving to discharge, cumulative incidence of post-traumatic epilepsy was 25% at 5 years and 32% at 15 years, an increase compared with historical reports. Among patients with one late seizure (>7 days post-trauma), the risk of seizure recurrence was 62% after 1 year and 82% at 10 years. Competing hazards regression identified age, decompressive hemicraniectomy, and intracranial infection as independent predictors of post-traumatic epilepsy. Patients with severe traumatic brain injury and a single late post-traumatic seizure will likely require long-term antiseizure medicines. ANN NEUROL 2022;92:663-669.