Genomic Variation-Mediating Fluconazole Resistance in Yeast

作者：Wenyao Wang, Hong‐Qing Cai, Si-Yuan Qu, Wei‐Hao Lin, Chengcheng Liang, Hao Liu, Ze‐Xiong Xie, Ying‐Jin Yuan · 发表于：Biomolecules · 年份：2022 · DOI：10.3390/biom12060845 · 被引用次数：22 · 研究领域：Antifungal resistance and susceptibility、Fungal Infections and Studies、Fungal and yeast genetics research

Fungal infections pose a serious and growing threat to public health. These infections can be treated with antifungal drugs by killing hazardous fungi in the body. However, the resistance can develop over time when fungi are exposed to antifungal drugs by generating genomic variations, including mutation, aneuploidy, and loss of heterozygosity. The variations could reduce the binding affinity of a drug to its target or block the pathway through which drugs exert their activity. Here, we review genomic variation-mediating fluconazole resistance in the yeast Candida, with the hope of highlighting the functional consequences of genomic variations for the antifungal resistance.