NCOA4: An Immunomodulation-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer

作者：Chenzheng Gu, Wenjing Chang, Junlu Wu, Yiwen Yao, Gege Liu, Yi Yuan, Wenqiang Quan, Zujun Sun, Anquan Shang, Dong Li · 发表于：Journal of Oncology · 年份：2022 · DOI：10.1155/2022/5242437 · 被引用次数：17 · 研究领域：Ferroptosis and cancer prognosis、RNA modifications and cancer、Estrogen and related hormone effects

Treatment of cancer in humans requires a thorough understanding of the multiple pathways by which it develops. Recent studies suggest that nuclear receptor coactivator 4 (NCOA4) may be a predictive biomarker for renal cancer. In the present work, TCGA, GEPIA, and several bioinformatics approaches were used to analyze the NCOA4 expression patterns, prognostic relevance, and association between NCOA4 and clinicopathological features and immune cell infiltration. We investigated NCOA4 expression in malignancies. Low NCOA4 expression was associated with poor overall survival in individuals with malignancies such as cholangiocarcinoma, colon adenocarcinoma, and clear cell renal carcinoma. We also analyzed NCOA4 DNA methylation in normal and primary tumor tissues and investigated possible functional pathways underlying NCOA4-mediated oncogenesis. In conclusion, downregulation of NCOA4 is associated with poor prognosis, and NCOA4 may be a predictive biomarker for COAD.