Total Synthesis of Natural Terpenoids Enabled by Cobalt Catalysis

作者：Shu Xiao, Likun Ai, Qichang Liu, Yang Bai-hui, Huang Jian, Wei Xue, Yang Chen · 发表于：Frontiers in Chemistry · 年份：2022 · DOI：10.3389/fchem.2022.941184 · 被引用次数：8 · 研究领域：Natural Compounds in Disease Treatment、Phytochemistry and Bioactivity Studies、Natural product bioactivities and synthesis

Transition metal catalysis plays an essential role in the total synthesis of natural products. Cobalt-mediated asymmetric catalysis has successfully been used as a primary or a secondary step in the total synthesis of natural products, especially terpenoids. Terpenoids represent one of the most prominent families among various categories of natural products, attracting immense attention due to their promising physiological activities. This review summarizes the recent advances toward the total synthesis of terpenoids by cobalt-mediated asymmetric catalysis, which may shed some light on their future synthetic efforts toward natural pesticides such as celanguline, azadirachtin, etc.